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[Initial experiences in diagnosis of graft rejection following clinical heart transplantation. Detection of graft-directed activated T-cells]. 1990
M Werner, and
U Otto, and
R Keitel, and
B Klötzer, and
K D Schürer, and
J Walther, and
S Vogt, and
H Ambrosius
Klinik für Chirurgie, Bereich Immunologie der Sektion Biowissenschaften, Karl-Marx-Universität Leipzig.
The binding of antigen-loaded carrier to mononuclear cells of heart transplant recipients has been investigated by means of an antigen-specific rosette technique. The increase of rosette forming cells and the inhibition of this reaction with monoclonal antibodies against activated T-cells is a sign of a beginning rejection. 3-6 days later infiltrating immunological competent cells are seen in biopsy.
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