-transparent.png){kind=logo}
We examined the brains of 385 mentally retarded adults aged 23-90 years without Down's syndrome (DS), metabolic disorder, or hydrocephalus to extend our knowledge about the occurrence of Alzheimer-type neuropathology in this population. Relevant measures of neuropathology also were related to selected information available from clinical records. The presence of one or more neurofibrillary tangles (NFT) and/or neuritic plaques (NP) was observed in 63.4% of all cases and varied with age. The prevalence of positive cases was higher when mental retardation was due to head trauma, congenital malformation, or familial factors and when a history of seizures was reported. Comprehensive morphometric analyses of neocortical, hippocampal and parahippocampal areas indicated that recommended age-specific quantitative criteria for the diagnosis of Alzheimer disease [Khachaturian ZS (1985) Arch Neurol 42:1097-1105] were met in 9.5% of cases less than 50 years of age, 54.2% between 50 and 65, 70% between 66 and 75, and 87% of the cases greater than 75 years of age. However, a limited immunohistochemical study revealed that in most cases the NP did not have a neuritic component containing paired helical filaments and in this respect most of the plaques observed in this population may differ from those most strongly associated with Alzheimer disease. In addition, substantial numbers of NFT were seen in frontal cortex, contrasting with results reported in the literature for nonretarded populations. The number of NP per mm2 consistently increased with age for all areas examined, while the relationship between NFT density and age varied across areas, and was clearly not monotonic.(ABSTRACT TRUNCATED AT 250 WORDS)
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
March 1989,
American journal of mental retardation : AJMR,
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
April 1990,
Journal of mental deficiency research,
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
February 1983,
Perceptual and motor skills,
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
January 1984,
Hepatology (Baltimore, Md.),
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
September 2002,
Journal of musculoskeletal & neuronal interactions,
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
January 1986,
Annals of the New York Academy of Sciences,
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
February 1977,
Lancet (London, England),
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
January 2006,
Revista de salud publica (Bogota, Colombia),
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
November 1975,
American journal of mental deficiency,
E R Popovitch, and
H M Wisniewski, and
M Barcikowska, and
W Silverman, and
C Bancher, and
E Sersen, and
G Y Wen
December 1985,
Lancet (London, England),
