BIOMAT Database Logo BIOMAT Database Logo

Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension. 1990

R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Department of Medicine, University of Texas Medical Branch, Galveston 77550.

Calcium channel blockers may alter parathyroid hormone secretion in vitro, which would alter calcium homeostasis. To determine the chronic effect of calcium channel blockade in vivo, we conducted a randomized, double blind, 16 week study comparing the effects of two pharmacologic antihypertensive agents, the calcium channel blocker diltiazem and the angiotensin-converting enzyme inhibitor captopril on parameters of calcium homeostasis. Both diltiazem and captopril lowered blood pressure to a similar degree. Neither drug produced any significant change in blood levels of total and ionized calcium, magnesium, or phosphorus, which affect the regulation of parathyroid hormone and vitamin D. In addition, at eight or 16 weeks following initiation, neither drug altered the serum levels of parathyroid hormone (PTH) or 1,25-(OH)2-vitamin D3 (1,25-D). Chronic calcium channel blockade with diltiazem does not alter serum parameters of calcium homeostasis and, thus, should not affect bone mineralization.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010281 Parathyroid Hormone A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates. Natpara,PTH (1-84),PTH(1-34),Parathormone,Parathyrin,Parathyroid Hormone (1-34),Parathyroid Hormone (1-84),Parathyroid Hormone Peptide (1-34),Hormone, Parathyroid
D012083 Renin A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19. Angiotensin-Forming Enzyme,Angiotensinogenase,Big Renin,Cryorenin,Inactive Renin,Pre-Prorenin,Preprorenin,Prorenin,Angiotensin Forming Enzyme,Pre Prorenin,Renin, Big,Renin, Inactive
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002121 Calcium Channel Blockers A class of drugs that act by selective inhibition of calcium influx through cellular membranes. Calcium Antagonists, Exogenous,Calcium Blockaders, Exogenous,Calcium Channel Antagonist,Calcium Channel Blocker,Calcium Channel Blocking Drug,Calcium Inhibitors, Exogenous,Channel Blockers, Calcium,Exogenous Calcium Blockader,Exogenous Calcium Inhibitor,Calcium Channel Antagonists,Calcium Channel Blocking Drugs,Exogenous Calcium Antagonists,Exogenous Calcium Blockaders,Exogenous Calcium Inhibitors,Antagonist, Calcium Channel,Antagonists, Calcium Channel,Antagonists, Exogenous Calcium,Blockader, Exogenous Calcium,Blocker, Calcium Channel,Blockers, Calcium Channel,Calcium Blockader, Exogenous,Calcium Inhibitor, Exogenous,Channel Antagonist, Calcium,Channel Blocker, Calcium,Inhibitor, Exogenous Calcium
D002216 Captopril A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline,Capoten,Lopirin,SQ-14,225,SQ-14,534,SQ-14225,SQ-14534,SQ 14,225,SQ 14,534,SQ 14225,SQ 14534,SQ14,225,SQ14,534,SQ14225,SQ14534
D004110 Diltiazem A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions. Aldizem,CRD-401,Cardil,Cardizem,Dilacor,Dilacor XR,Dilren,Diltiazem Hydrochloride,Diltiazem Malate,Dilzem,Tiazac,CRD 401,CRD401

Related Publications

R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Effects of a new calcium channel blocker, TA 3090, on serum lipoprotein levels in mild to moderate essential hypertension.
January 1990, Clinical therapeutics,
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
[Effects of a calcium antagonist, verapamil, on mild-moderate essential arterial hypertension].
January 1989, Anales de medicina interna (Madrid, Spain : 1984),
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Effects of essential fatty acids on mild to moderate essential hypertension.
July 1988, Prostaglandins, leukotrienes, and essential fatty acids,
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Calcium-channel blockade (nitrendipine) in combination with ACE inhibition (captopril) in the treatment of mild to moderate hypertension.
June 1989, Cardiovascular drugs and therapy,
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
The significance of calcium and calcium channel blockade in essential hypertension.
December 1985, Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Effects of calcium channel blockade on histamine induced bronchoconstriction in mild asthma.
August 1984, Thorax,
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Enhanced vasodilatation in essential hypertension by calcium channel blockade with verapamil.
January 1982, Hypertension (Dallas, Tex. : 1979),
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Urinary kallikrein in mild to moderate essential hypertension.
January 1985, Advances in prostaglandin, thromboxane, and leukotriene research,
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Proceedings: Oxprenolol in mild to moderate essential hypertension.
January 1974, Scottish medical journal,
R Townsend, and D J DiPette, and R R Evans, and W R Davis, and A Green, and G A Graham, and J M Wallace, and O B Holland
Multifocal electroretinogram in mild to moderate essential hypertension.
July 2008, Clinical and experimental hypertension (New York, N.Y. : 1993),
Copied contents to your clipboard!