BIOMAT Database Logo BIOMAT Database Logo

Experimental canine anaphylaxis: cyclic nucleotides, histamine, and lung function. 1979

S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold

We studied the effects of Ascaris suum antigen (iv) in 32 natively allergic, anesthetized dogs. After thoracotomy, bilateral cervical vagotomy, and propranolol, samples of peripheral lung frozen in situ were obtained for measurement of cyclic nucleotides and histamine. Following Ascaris, lung histamine decreased 20.4 +/- 3.7% (mean +/- SE), cAMP increased 391 +/- 122%, and cGMP increased 110 +/- 20% with increased plasma histamine and physiological changes of anaphylaxis. No significant changes occurred in 10 control dogs. Release of histamine, reflecting immunological degranulation of mast cells, correlated closely with the physiological effects of anaphylaxis. beta-Adrenergic stimulation with isoproterenol prevented these physiological effects of anaphylaxis in three dogs studied. Furthermore, the level of cAMP induced in lung tissue by beta-adrenergic stimulation in these dogs correlated with the degree of inhibition of immunologically induced histamine release. These results illustrate the suitability of this experimental preparation to study the biochemical and physiological mechanisms of anaphylaxis in vivo.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008170 Lung Compliance The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562) Compliance, Lung,Compliances, Lung,Lung Compliances
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006152 Cyclic GMP Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed) Guanosine Cyclic 3',5'-Monophosphate,Guanosine Cyclic 3,5 Monophosphate,Guanosine Cyclic Monophosphate,Guanosine Cyclic-3',5'-Monophosphate,3',5'-Monophosphate, Guanosine Cyclic,Cyclic 3',5'-Monophosphate, Guanosine,Cyclic Monophosphate, Guanosine,Cyclic-3',5'-Monophosphate, Guanosine,GMP, Cyclic,Guanosine Cyclic 3',5' Monophosphate,Monophosphate, Guanosine Cyclic
D006632 Histamine An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Ceplene,Histamine Dihydrochloride,Histamine Hydrochloride,Peremin
D000242 Cyclic AMP An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH. Adenosine Cyclic 3',5'-Monophosphate,Adenosine Cyclic 3,5 Monophosphate,Adenosine Cyclic Monophosphate,Adenosine Cyclic-3',5'-Monophosphate,Cyclic AMP, (R)-Isomer,Cyclic AMP, Disodium Salt,Cyclic AMP, Monoammonium Salt,Cyclic AMP, Monopotassium Salt,Cyclic AMP, Monosodium Salt,Cyclic AMP, Sodium Salt,3',5'-Monophosphate, Adenosine Cyclic,AMP, Cyclic,Adenosine Cyclic 3',5' Monophosphate,Cyclic 3',5'-Monophosphate, Adenosine,Cyclic Monophosphate, Adenosine,Cyclic-3',5'-Monophosphate, Adenosine,Monophosphate, Adenosine Cyclic
D000707 Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death. Anaphylactic Reaction,Anaphylactoid Reaction,Anaphylactoid Shock,Shock, Anaphylactic,Anaphylactic Reactions,Anaphylactic Shock,Anaphylactoid Reactions,Reaction, Anaphylactic,Reaction, Anaphylactoid,Shock, Anaphylactoid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000941 Antigens Substances that are recognized by the immune system and induce an immune reaction. Antigen
D001200 Ascaris A genus of nematodes of the superfamily ASCARIDOIDEA whose species usually inhabit the intestine. Ascari

Related Publications

S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
Histamine H3 receptor blockade improves cardiac function in canine anaphylaxis.
October 1999, American journal of respiratory and critical care medicine,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
Accumulation of histamine and cyclic nucleotides in lung tissue during chronic hypobaric hypoxia.
January 1978, Lung,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
Histamine, cyclic nucleotides, and gastric parietal cell secretion.
January 1980, Advances in cyclic nucleotide research,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
Cyclic nucleotides and tubule function.
January 1980, Advances in cyclic nucleotide research,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
Cyclic nucleotides and cardiac function.
February 1979, Circulation research,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
[Cyclic nucleotides and intestinal function].
October 1976, Klinicheskaia meditsina,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
[Influencing experimental histamine asthma and serum anaphylaxis].
May 1958, Orvosi hetilap,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
[Cyclic nucleotides in experimental glaucoma].
October 1988, Biulleten' eksperimental'noi biologii i meditsiny,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
[Cyclic nucleotides in experimental uveitis].
January 1985, Voprosy meditsinskoi khimii,
S C Lazarus, and S E Chesrown, and M J Frey, and B R Reed, and T O Mjörndal, and W M Gold
[Participation of histamine and cyclic nucleotides in the regulation of gastric secretion in experimental thyrotoxicosis].
February 1983, Biulleten' eksperimental'noi biologii i meditsiny,
Copied contents to your clipboard!