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The ATP-sensitive potassium channel current (IK-ATP) was studied in excised inside-out patches from rat ventricular cells at 20-23 degrees C. The bath solution contained 140 mM KF, and the pipette solution contained 140 mM KCl and 1.2 mM MgCl2. ATP (0.5 mM) in the bath inhibited IK-ATP. In the absence of ATP, 10 microM quinidine decreased open probability 67 +/- 1% (n = 6) at -50 mV and 28 +/- 12% at -130 mV (n = 5) without affecting single channel conductance (48-52 pS). The block increased with 25 and 50 microM quinidine and could be reversed on washing quinidine for several minutes. Interburst (closed) intervals were increased by quinidine, whereas open and closed time distributions within bursts were not changed. We conclude that quinidine blocks IK-ATP in a "slow" and voltage-dependent manner in clinically relevant concentrations. Because of the postulated role for IK-ATP in cardiac ischemia, quinidine block of this channel may play a role in ischemic arrhythmias.
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
January 1988,
Annual review of neuroscience,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
November 1990,
Stroke,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
June 2003,
Circulation,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
April 1999,
Endocrine reviews,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
February 2016,
Molecular medicine reports,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
December 1991,
The American journal of physiology,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
June 2016,
Cardiac electrophysiology clinics,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
April 2000,
Anesthesiology,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
July 1984,
The Journal of physiology,
A I Undrovinas, and
N Burnashev, and
D Eroshenko, and
I Fleidervish, and
C F Starmer, and
J C Makielski, and
L V Rosenshtraukh
August 1988,
Pflugers Archiv : European journal of physiology,
