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The actions of diazepam and gamma-hydroxybutyrate (GHB) were assessed on the sleep-wakefulness cycle of male Wistar rats. One and 2 mg/kg diazepam and 12.5 mg/kg GHB had no effects on the sleep variables. After 25 mg/kg GHB, slow wave sleep (SWS2) was significantly increased. Following the combined administration of non-effective doses of GHB and diazepam, significantly higher amounts of SWS2 at the expense of wakefulness were obtained. The injection of a subconvulsant dose of bicuculline (2.5 mg/kg) prior to treatments which significantly increased SWS2 prevented this effect to show up. It is suggested that the actions of GHB and diazepam on the sleep-awake cycle are related to the same neurotransmitter system.
J M Monti, and
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L D'Angelo
April 1977,
Biological psychiatry,
J M Monti, and
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L D'Angelo
April 1969,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
J M Monti, and
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January 1986,
Psychopharmacology,
J M Monti, and
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January 1998,
Sleep research online : SRO,
J M Monti, and
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Farmakologiia i toksikologiia,
J M Monti, and
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L D'Angelo
June 1992,
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J M Monti, and
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L D'Angelo
February 1980,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
J M Monti, and
H Altier, and
L D'Angelo
January 1980,
Neuropharmacology,
J M Monti, and
H Altier, and
L D'Angelo
March 1982,
Journal of neurochemistry,
J M Monti, and
H Altier, and
L D'Angelo
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Psychopharmacology,
