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Serum levels of tumor-associated glycoprotein (TAG-72) were measured using a two-step sandwich radioimmunoassay kit in 281 patients with digestive cancers and 135 patients with benign digestive diseases. The positive rates of TAG-72 with the cut-off values of 2.2 and 4.0 U/ml were high in pancreatobiliary (56%, 38%), gastric (49%, 37%) and colorectal (62%, 29%) cancers, while the false-positive rate in benign diseases was 11%, 0.7% respectively. Very high levels were found in patients with advanced cancer. TAG-72 was positive in 17 (greater than 2.2 U/ml) and 7 (greater than 4.0 U/ml) out of 60 CEA-negative patients, and in 7 (greater than 2.2 U/ml) and 3 (greater than 4.0 U/ml) out of 17 CA19-9-negative patients. TAG-72 might be a useful serum marker for digestive cancers, especially gastric and colorectal cancers.
Y Motoo, and
Y Satomura, and
H Kawakami, and
H Watanabe, and
H Ohta, and
T Okai, and
N Sawabu
December 1992,
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Y Motoo, and
Y Satomura, and
H Kawakami, and
H Watanabe, and
H Ohta, and
T Okai, and
N Sawabu
April 1993,
The Journal of clinical endocrinology and metabolism,
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N Sawabu
January 1990,
The Journal of nuclear medicine and allied sciences,
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January 1992,
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N Sawabu
July 1990,
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Y Motoo, and
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H Ohta, and
T Okai, and
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September 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
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March 1992,
Cancer research,
Y Motoo, and
Y Satomura, and
H Kawakami, and
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H Ohta, and
T Okai, and
N Sawabu
July 1992,
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists,
