Effect of curcumin on lipid peroxidation, early ultrastructural findings and neurological recovery after experimental spinal cord contusion injury in rats. 2012

Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
M.H. Diskapi Yildirim Beyazit Education and Research Hospital, 1st Neurosurgery Clinic, Ankara, Turkey. ahmetmetinsanli@hotmail.com

OBJECTIVE After acute spinal cord injury (SCI), a large number of axons are lost by a cascade of pathophysiological events known as a secondary injury. The main aim of the current study was to investigate the potential neuroprotective effects of curcumin on lipid peroxidation (LPO), neurological function, and ultrastructural findings after SCI. METHODS Forty adult Wistar albino rats were randomized into five groups: control, SCI alone (50 g/cm weight drop), methylprednisolone sodium succinate (MPSS) (30 mg/kg), curcumin + dimethyl sulfoxide (DMSO) (300 mg/kg), and DMSO alone (0.1 mg/kg). RESULTS Administration of curcumin significantly decreased LPO in first 24 hours. However, there were no differences in the neurological scores of injured rats between the medication groups and the control group. Curcumin was more effective than DMSO and MPSS in reducing LPO, whereas DMSO was more effective than curcumin and MPSS in minimizing ultrastuctural changes. The results of this study indicate that curcumin exerts a beneficial effect by decreasing LPO and may reduce tissue damage. CONCLUSIONS Since ultrastructural and neurological findings does not support biochemical finding, our findings do not exclude the possibility that curcumin has a protective effect on the spinal cord ultrastructure and neurological recovery after SCI. A combination of curcumin with other vehicle may also have a considerable synergy in protecting spinal cord.

UI MeSH Term Description Entries
D008315 Malondialdehyde The dialdehyde of malonic acid. Malonaldehyde,Propanedial,Malonylaldehyde,Malonyldialdehyde,Sodium Malondialdehyde,Malondialdehyde, Sodium
D008776 Methylprednisolone Hemisuccinate A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies. Methylprednisolone Succinate,6 alpha-Methylprednisolone Sodium Hemisuccinate,A-MethaPred,Methylprednisolone Hemisuccinate Monosodium Salt,Methylprednisolone Sodium Hemisuccinate,Methylprednisolone Sodium Succinate,Solu-Medrol,Solumedrol,Urbason-Soluble,Hemisuccinate, Methylprednisolone,Sodium Hemisuccinate, Methylprednisolone,Sodium Succinate, Methylprednisolone,Succinate, Methylprednisolone,UrbasonSoluble
D008928 Mitochondria Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed) Mitochondrial Contraction,Mitochondrion,Contraction, Mitochondrial,Contractions, Mitochondrial,Mitochondrial Contractions
D009413 Nerve Fibers, Myelinated A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves. A Fibers,B Fibers,Fiber, Myelinated Nerve,Fibers, Myelinated Nerve,Myelinated Nerve Fiber,Myelinated Nerve Fibers,Nerve Fiber, Myelinated
D003474 Curcumin A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes. 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-,Curcumin Phytosome,Diferuloylmethane,Mervia,Turmeric Yellow,Phytosome, Curcumin,Yellow, Turmeric
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260 Female Females
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000894 Anti-Inflammatory Agents, Non-Steroidal Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Analgesics, Anti-Inflammatory,Aspirin-Like Agent,Aspirin-Like Agents,NSAID,Non-Steroidal Anti-Inflammatory Agent,Non-Steroidal Anti-Inflammatory Agents,Nonsteroidal Anti-Inflammatory Agent,Anti Inflammatory Agents, Nonsteroidal,Antiinflammatory Agents, Non Steroidal,Antiinflammatory Agents, Nonsteroidal,NSAIDs,Nonsteroidal Anti-Inflammatory Agents,Agent, Aspirin-Like,Agent, Non-Steroidal Anti-Inflammatory,Agent, Nonsteroidal Anti-Inflammatory,Anti-Inflammatory Agent, Non-Steroidal,Anti-Inflammatory Agent, Nonsteroidal,Anti-Inflammatory Analgesics,Aspirin Like Agent,Aspirin Like Agents,Non Steroidal Anti Inflammatory Agent,Non Steroidal Anti Inflammatory Agents,Nonsteroidal Anti Inflammatory Agent,Nonsteroidal Anti Inflammatory Agents,Nonsteroidal Antiinflammatory Agents

Related Publications

Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
October 1999, Journal of neurosurgery,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
April 2004, Neurosurgical review,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
January 2021, Turkish neurosurgery,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
September 1998, Spinal cord,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
January 1998, Neurosurgical review,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
January 1998, Neurosurgical review,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
January 2005, Restorative neurology and neuroscience,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
June 2018, Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
July 1999, Spinal cord,
Ahmet Metin Sanli, and Erhan Turkoglu, and Gokhan Serbes, and Mustafa Fevzi Sargon, and Omer Besalti, and Kamer Kilinc, and Alper Irak, and Zeki Sekerci
June 2002, Journal of neurotrauma,
Copied contents to your clipboard!