Alpha basic crystallin expression in canine mammary tumors. 2012

Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
Department of Pathology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Kurupelit, Samsun 55139, Turkey. tguvenc@omu.edu.tr

The aim of this study was to evaluate prognostic and/or diagnostic factors of canine mammary tumors by immunohistochemically analyzing the expression of alpha basic crystallin (αB-c). For this, formalin-fixed, paraffin-embedded blocks of 51 naturally-occurring canine mammary tumors (11 benign and 40 malignant) were used. Tissue from eight normal canine mammary glands were served as a control. Immunohistochemically, in the control mammary tissues, a few luminal epithelial cells were αB-c positive but myoepithelial cells were negative. In benign or simple type malignant tumors, αB-c expression was observed in luminal epithelial cells while the myoepithelial basal cells were negative. In benign or complex type malign tumors, positive staining was predominantly found in the cytoplasm of epithelial cells. Immunoreactivity of αB-c was also observed in neoplastic myoepithelial cells. Statistically, the number of cells immunolabeled with αB-c was found to be significantly different among tissues from normal canine mammary glands, benign lesions, and malignant tumors (p < 0.05). αB-c immunoreactivity was higher in malignant tumors than the control mammary tissues (p < 0.001). Data obtained in the current study revealed a strong association between high expression levels of αB-c and primary mammary gland tumors in canines.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D004283 Dog Diseases Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used. Canine Diseases,Canine Disease,Disease, Canine,Disease, Dog,Diseases, Canine,Diseases, Dog,Dog Disease
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015674 Mammary Neoplasms, Animal Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL). Animal Mammary Carcinoma,Mammary Carcinoma, Animal,Mammary Neoplasms,Neoplasms, Mammary,Animal Mammary Carcinomas,Animal Mammary Neoplasm,Animal Mammary Neoplasms,Carcinoma, Animal Mammary,Carcinomas, Animal Mammary,Mammary Carcinomas, Animal,Mammary Neoplasm,Mammary Neoplasm, Animal,Neoplasm, Animal Mammary,Neoplasm, Mammary,Neoplasms, Animal Mammary
D016015 Logistic Models Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor. Logistic Regression,Logit Models,Models, Logistic,Logistic Model,Logistic Regressions,Logit Model,Model, Logistic,Model, Logit,Models, Logit,Regression, Logistic,Regressions, Logistic
D038201 alpha-Crystallins A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits. Crystallins, alpha,alpha-Crystallin,alpha Crystallin,alpha Crystallins

Related Publications

Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
August 2011, Histopathology,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
March 2003, Veterinary pathology,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
November 1993, International journal of cancer,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
August 2016, BMC veterinary research,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
January 1970, Pathologia veterinaria,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
January 2011, Genetics and molecular research : GMR,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
July 2015, BMC veterinary research,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
June 2018, BMC veterinary research,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
May 2003, The Veterinary clinics of North America. Small animal practice,
Tolga Guvenc, and Mustafa Yavuz Gulbahar, and Murat Yarim, and Yonca Betil Kabak, and Onder Karayigit, and Mahmut Sozmen
May 1985, The Veterinary clinics of North America. Small animal practice,
Copied contents to your clipboard!