Hemimaxillectomy patients present with abrupt alterations in the physiologic processes of the maxillae, along with increased anxiety levels due to sudden impairment in esthetics, mastication, speech, deglutition and hypernasal speech. Such patients should be rehabilitated as early as possible, in the postoperative phase with the help of careful preoperative planning by the surgeon and the prosthodontist. This case report illustrates the multidisciplinary approach to rehabilitate a patient, who had undergone maxillectomy on the right side, due to carcinoma alveolus. The transitional prosthesis given in this case used Tissue conditioners, which, because of their viscoelastic nature, ensure continuous adaptation, helping peripheral seal and retention. This greatly reduces discomfort and nasal reflux and improves speech.