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We studied the integrity of the alveolo-capillary barrier during different forms of anaesthesia by measuring the pulmonary clearance of inhaled 99mTc-DTPA. We studied four groups of rabbits. Groups I and II were anaesthetized with nembuthal only and the fractional concentration of inspired oxygen (F1O2) was 0.30 and 1.00, respectively. Groups III and IV were anaesthetized with 1% halothane and F1O2 was 0.30 and 0.99, respectively. 99mTc-DTPA was administered as a fine aerosol and the clearance of the tracer from the lungs was subsequently measured with a gamma camera. The mean half-life of the tracer in the lungs in Groups I-IV was 60, 58, 59 and 26 min, respectively. The rapid pulmonary clearance of 99mTc-DTPA in Group IV indicates that halothane in combination with high oxygen concentration increases the permeability of the alveolo-capillary barrier. This may be due to effects on the pulmonary surfactant system and/or the alveolar epithelium.
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
March 1997,
Clinical physiology (Oxford, England),
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
September 1994,
Clinical physiology (Oxford, England),
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
March 1988,
Journal of applied physiology (Bethesda, Md. : 1985),
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
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The American review of respiratory disease,
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
July 1994,
Journal of applied physiology (Bethesda, Md. : 1985),
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
March 2007,
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...,
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
August 1992,
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases,
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
December 1992,
The American review of respiratory disease,
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
September 1986,
The American review of respiratory disease,
P Wollmer, and
W Schairer, and
J A Bos, and
W Bakker, and
E P Krenning, and
B Lachmann
November 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
