Biomaterial Database

California's Proposition 65: extrapolating animal toxicity to humans. 1990

W W Kilgore

Department of Environmental Toxicology, University of California-Davis 95616.

In 1986, the voters of California passed a law regarding the concept of extrapolating animal toxicity data to humans. The California Safe Drinking Water and Toxic Enforcement Act of 1986, known as Proposition 65, does five things: 1. It creates a list of chemicals (including a number of agricultural chemicals) known to cause cancer or reproductive toxicity; 2. It limits discharges of listed chemicals to drinking water sources; 3. It requires prior warning before exposure to listed chemicals by anyone in the course of doing business; 4. It creates a list of chemicals requiring testing for carcinogenicity or reproductive toxicity; and 5. It requires the Governor to consult with qualified experts (a 12-member "Scientific Advisory Panel" was appointed) as necessary to carry out his duties. This paper discusses the details and implications of this proposition. Areas of responsibility have been assigned. The definition of significant risk is being addressed.

UI	MeSH Term	Description	Entries
D011640	Public Policy	A course or method of action selected, usually by a government, from among alternatives to guide and determine present and future decisions.	Social Policy,Affirmative Action,Migration Policy,Population Policy,Social Protection,Action, Affirmative,Migration Policies,Policies, Migration,Policies, Population,Policies, Public,Policies, Social,Policy, Migration,Policy, Population,Policy, Public,Policy, Social,Population Policies,Protection, Social,Public Policies,Social Policies
D002140	California	State bounded on the east by Nevada and Arizona, on the south by Mexico and the Pacific Ocean on the south and west, and on the north by Oregon.
D002274	Carcinogens, Environmental	Carcinogenic substances that are found in the environment.	Environmental Carcinogens
D004784	Environmental Monitoring	The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.	Monitoring, Environmental,Environmental Surveillance,Surveillance, Environmental
D004787	Environmental Pollution	Contamination of the air, bodies of water, or land with substances that are harmful to human health and the environment.	Pollution, Environmental,Soil Pollution,Pollution, Soil
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000014	Abnormalities, Drug-Induced	Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	Drug-Induced Abnormalities,Abnormalities, Drug Induced,Abnormality, Drug-Induced,Drug Induced Abnormalities,Drug-Induced Abnormality
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D014877	Water Pollution, Chemical	Adverse effect upon bodies of water (LAKES; RIVERS; seas; groundwater etc.) caused by CHEMICAL WATER POLLUTANTS.	Chemical Water Pollution,Chemical Water Pollutions,Pollution, Chemical Water,Pollutions, Chemical Water,Water Pollutions, Chemical