Biomaterial Database

[Ocular features of multiple endocrine neoplasia type 2b]. 2012

Zhi-qiao Zhang, and Xiao-wei Liu, and Fang-tian Dong

Department of Ophthalmology, Chinese Academy of Medical Sciences, Beijing, China.

OBJECTIVE To analyze the ocular features of multiple endocrine neoplasia type 2b (MEN 2b). METHODS Three cases with MEN 2b were reviewed and their ocular features analyzed. RESULTS All patients had medullary thyroid carcinoma and thickened corneal nerve fibers. Adrenal pheochromocytoma, oral mucosal neuroma, marfanoid body habitus, eyelid nodule and conjunctival nodule were found in two patients. And iris nodule was found in one patient. CONCLUSIONS The most common ocular manifestations of MEN 2b is thickened corneal nerve fibers.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D003315	Cornea	The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)	Corneas
D005123	Eye	The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.	Eyes
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective
D055815	Young Adult	A person between 19 and 24 years of age.	Adult, Young,Adults, Young,Young Adults
D018814	Multiple Endocrine Neoplasia Type 2b	Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.	MEN 2b,MEN 3,Neoplasia, Multiple Endocrine Type 2b,Neoplasms, Multiple Endocrine Type 2b,MEA 2b,MEA IIb,MEN III,MEN IIb,MEN2b,Mucosal Neuroma Syndrome,Multiple Endocrine Neoplasia, Type 2b,Multiple Endocrine Neoplasia, Type IIb,Multiple Endocrine Neoplasms Type 2b,Neuromata, Mucosal, With Endocrine Tumors,Wagenmann-Froboese Syndrome,Mucosal Neuroma Syndromes,Neuroma Syndrome, Mucosal,Syndrome, Wagenmann-Froboese,Wagenmann Froboese Syndrome