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Preparation of hollow magnetite microspheres and their applications as drugs carriers. 2012

Francisco Márquez, and Gloria M Herrera, and Teresa Campo, and María Cotto, and José Ducongé, and José M Sanz, and Eduardo Elizalde, and Oscar Perales, and Carmen Morant
School of Science and Technology, University of Turabo, Gurabo 00778, PR, USA. fmarquez@suagm.edu.

Hollow magnetite microspheres have been synthesized by a simple process through a template-free hydrothermal approach. Hollow microspheres were surface modified by coating with a silica nanolayer. Pristine and modified hollow microparticles were characterized by field-emission electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, FT-IR and Raman spectroscopy, and VSM magnetometry. The potential application of the modified hollow magnetite microspheres as a drug carrier was evaluated by using Rhodamine B and methotrexate as model drugs. The loading and release kinetics of both molecules showed a clear pH and temperature dependent profile. GRAPHICAL Hollow magnetite microspheres have been synthesized. Load-release experiments with Rhodamine-B as a model drug and with Methotrexate (chemotherapy drug used in treating certain types of cancer) demonstrated the potential applications of these nanostructures in biomedical applications.

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