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Experimental acute lung injury mediated by reactive metabolites of oxygen can be inhibited by the antioxidant enzymes catalase and superoxide dismutase (SOD). However, the specific time interval during which these enzymes must be present in order to cause protection is not well defined. Using two experimental models of oxidant-dependent acute lung injury, one involving the intratracheal injection of glucose, glucose oxidase, and lactoperoxidase and the other involving the intravenous injection of cobra venom factor (CVF), we investigated the effects of delaying antioxidant administration on the outcome of the inflammatory response. In both cases, the protective effects of catalase and SOD were rapidly attenuated when their administration was delayed for a short period of time. For example, intratracheal catalase resulted in 98% protection when given simultaneously with the glucose oxidase and lactoperoxidase, but only 13% protection when the catalase was delayed 4 min. Likewise, in the CVF-induced lung injury model, intravenous catalase resulted in 40% protection when given simultaneously with the CVF, but only 2% protection when the catalase was delayed 20 min, even though the peak of the injury occurred hours after the initiation of the injury. A similar time dependence was seen with SOD. These results indicate that antioxidant therapy is required early in the course of oxygen radical-mediated acute lung injury for effective protection.
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
April 1983,
The Journal of trauma,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
December 1989,
Annals of surgery,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
August 1983,
The Journal of thoracic and cardiovascular surgery,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
December 1986,
Archives internationales de physiologie et de biochimie,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
November 2013,
Influenza and other respiratory viruses,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
June 1994,
The Journal of surgical research,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
February 2022,
Cell death discovery,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
January 2017,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
October 2005,
European journal of anaesthesiology,
D E Gannon, and
X M He, and
P A Ward, and
J Varani, and
K J Johnson
August 1990,
The Annals of thoracic surgery,
