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N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) proved to be a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine (BOP), and N-nitroso-2,6-dimethylmorpholine and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular adenocarcinomas than did N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine, and these neoplasms showed a great tendency for invasion and metastasis. Also, HPOP induced tumors of the forestomach, liver, gallbladder, kidneys, and vagina (as did BOP). However, HPOP [unlike BOP, but like N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine] led to tumor development in the nasal cavity, larynx, trachea, intestine, Harderian gland, lips, and flank organ. The possible mechanisms of HPOP carcinogenicity are discussed.
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
March 1984,
Journal of the National Cancer Institute,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
May 1977,
Journal of the National Cancer Institute,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
April 1981,
Cancer letters,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
April 1989,
Carcinogenesis,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
March 1976,
Cancer letters,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
April 1978,
Journal of the National Cancer Institute,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
November 1990,
Carcinogenesis,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
August 1980,
Cancer letters,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
August 1976,
Cancer research,
P Pour, and
L Wallcave, and
R Gingell, and
D Nagel, and
T Lawson, and
S Salmasi, and
S Tines
August 1985,
Cancer research,
