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Nude mice bearing CX-1 colon tumors were injected with 50 microCi 125I-labeled monoclonal antibody (MAb) B72.3. Radioactivity in tumors was studied with the gamma detecting probe (GDP) on days 1, 3, 7, and 10 after MAb injection. On each day, two mice were sacrificed and sections were examined with autoradiography (ARG), immunoperoxidase methods (IMP), and routine stains. Mean probe counts showed increasing tumor to background ratios and ARG demonstrated a progressive increase in radionuclide in the tumors. The distribution of 125I was primarily around the vascular spaces on day 1, but by day 3 and progressively it appeared in tumor gland lumina and necrotic areas. A regional correlation was shown between radionuclide in vascular spaces and its sequestration in tumor elements.
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
March 1989,
International journal of radiation oncology, biology, physics,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
October 1990,
Obstetrics and gynecology,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
December 1984,
Cancer research,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
January 1989,
Journal of investigative surgery : the official journal of the Academy of Surgical Research,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
January 1995,
Anticancer research,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
July 1989,
Surgery, gynecology & obstetrics,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
November 1984,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
August 1997,
Cancer biotherapy & radiopharmaceuticals,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
January 1986,
Cancer immunology, immunotherapy : CII,
J W Sampsel, and
G Hinkle, and
C Nieroda, and
J Ignaszewski, and
M Thurston, and
E W Martin
May 1995,
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy,
