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[The individual characteristics of the excretion of benzo(a)pyrene metabolites in rats]. 1990

I V Savochkina, and P P Dikun, and M A Zabezhinskiĭ, and V A Iamshanov, and A Ia Likhachev

Assessment of individual peculiarities of carcinogen metabolism in the body opens up new vistas in predicting individual sensitivity to these agents. The authors developed a spectrofluorometric [correction of spectrofluorescence] technique to assay concentrations of carcinogenic benzo(a)-pyrene (BP) metabolite (7,8-BP) and a product of its detoxication (3-BP) in excreta of male rats who had been given a single dose of 200 mg/kg of benzo(a)pyrene intraperitoneally. Ten-thirty times daily variations in individual levels of both metabolites were accompanied by less variation in their total amount. Parameters of BP metabolism perhaps can be used for predicting individual risk of BP-induced tumor development.

UI MeSH Term Description Entries
D008297 Male Males
D004101 Dihydroxydihydrobenzopyrenes Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity. Benzopyrene Dihydrodiols,Dihydrobenzopyrene Diols,Dihydrodiolbenzopyrenes,Dihydrodiols, Benzopyrene,Diols, Dihydrobenzopyrene
D005243 Feces Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001564 Benzo(a)pyrene A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke. 3,4-Benzopyrene,3,4-Benzpyrene,3,4 Benzopyrene,3,4 Benzpyrene
D001580 Benzopyrenes A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it. Benzpyrene
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D013050 Spectrometry, Fluorescence Measurement of the intensity and quality of fluorescence. Fluorescence Spectrophotometry,Fluorescence Spectroscopy,Spectrofluorometry,Fluorescence Spectrometry,Spectrophotometry, Fluorescence,Spectroscopy, Fluorescence
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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