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Caroli's disease is one of the rare congenital conditions associated with the cystic dilatation of intrahepatic bile ducts. This is a case report of a 41-year-old Japanese male who complained of jaundice and general fatigue at the age of 34 for the first time. He was clinically diagnosed as having Caroli's disease by physical examination and image analyses study. The patient died after seven years and three months from the onset of the disease on account of renal function impairment. An autopsy was performed, revealing cystic dilatation of the intrahepatic bile duct, associated with a cirrhotic liver and also evidence of portal hypertension, substantiated by esophageal varices and splenomegaly. The liver weighed approximately 2,200 g. A histological investigation revealed typical morphological evidence of cirrhotic glomerulopathy and tubular degeneration with the presence of calcium casts in the dilated tubuli. The lung revealed diffuse alveolar damage with partial organization associated with remarkable polymorphonuclear and macrophagic infiltration. In this paper, the pathogenesis of the cirrhotic change, biliary duct abnormality and potential malignant transformation in the liver are discussed in relation to Caroli's disease.
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
December 1987,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
September 1991,
HPB surgery : a world journal of hepatic, pancreatic and biliary surgery,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
September 1962,
Nagasaki Igakkai zasshi = Nagasaki medical journal,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
January 1981,
The Kurume medical journal,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
November 1990,
Nihon Kyobu Shikkan Gakkai zasshi,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
August 2003,
Digestive diseases and sciences,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
September 1988,
Revista clinica espanola,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
January 2011,
Onkologie,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
September 1989,
Minerva cardioangiologica,
M Milanga, and
H Yamada, and
S Ishiharajima, and
N Yamanaka, and
G Asano, and
Y Fukuda, and
T Suzuki, and
H Hoshinaga, and
K Taguchi, and
H Kuroda
January 2022,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
