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The reproductive effect of N,N-dimethylformamide (DMF) administered epicutaneously to rats was examined. The rats were dosed on gestation days 6-15 or on gestation days 1-20 at dose levels of up to 2 ml DMF kg-1 body weight. Body weight, weight gain and pregnancy rate were reduced in those rats receiving 2 ml DMF kg-1 body weight per day on days 6-15. A reduction in the number of live fetuses and in fetal weight, as well as an increase in postimplantation loss, were also observed at this dose level. Similar but more pronounced effects were observed in rats dosed on days 1-20 with 2 ml DMF kg-1 body weight. The lowest effect level was 1 ml DMF kg-1 body weight. No other dose-related effects were found in this study.
E Hansen, and
O Meyer
October 1996,
Regulatory toxicology and pharmacology : RTP,
E Hansen, and
O Meyer
January 1997,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
E Hansen, and
O Meyer
June 2004,
Regulatory toxicology and pharmacology : RTP,
E Hansen, and
O Meyer
August 2004,
Regulatory toxicology and pharmacology : RTP,
E Hansen, and
O Meyer
April 1998,
Regulatory toxicology and pharmacology : RTP,
E Hansen, and
O Meyer
December 1987,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
E Hansen, and
O Meyer
June 1983,
Teratology,
E Hansen, and
O Meyer
January 1990,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
E Hansen, and
O Meyer
September 1984,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
