-transparent.png){kind=logo}
Early treatment failure during treatment of Plasmodium falciparum malaria with atovaquone-proguanil in the Republic of Ivory Coast. 2012
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
Unité de Parasitologie - Unité de Recherche pour les Maladies Infectieuses et Tropicales Emergentes - UMR 6236, Institut de Recherche Biomédicale des Armées, Marseille, France. nathalie_wurtz@yahoo.fr
The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone-proguanil (Malarone®) has shown high efficacy against Plasmodium falciparum with only mild side-effects. Treatment failures have been attributed to suboptimal dosages or to parasite resistance resulting from a point mutation in the cytochrome b gene. In this paper, a case of early treatment failure was reported in a patient treated with atovaquone-proguanil; this failure was not associated with a mutation in the parasite cytochrome b gene, with impaired drug bioavailability, or with re-infection.
Related Publications
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
February 2008,
Emerging infectious diseases,
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
November 2011,
Presse medicale (Paris, France : 1983),
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
August 2002,
The Pediatric infectious disease journal,
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
June 1996,
Lancet (London, England),
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
January 2021,
The Cochrane database of systematic reviews,
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
April 2023,
Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias,
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
September 2018,
Turkiye parazitolojii dergisi,
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
January 2011,
Medecine et maladies infectieuses,
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
January 1988,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
Nathalie Wurtz, and
Aurélie Pascual, and
Adeline Marin-Jauffre, and
Housem Bouchiba, and
Nicolas Benoit, and
Marc Desbordes, and
Maryse Martelloni, and
Vincent Pommier de Santi, and
Georges Richa, and
Nicolas Taudon, and
Bruno Pradines, and
Sébastien Briolant
January 2000,
The Journal of infectious diseases,
