Decompressive craniectomy (DC) is used to relieve intractable intracranial hypertension and/or to prevent or reverse cerebral herniation. Significant controversy exists on selection of candidates, timing of the procedure and neurologic outcomes. Furthermore, the cerebral hemodynamic consequences post-DC have been researched only recently. We report on two consecutive patients who underwent DC in our institution and reviewed the literature on cerebral blood flow changes post-craniectomy. One patient had unilateral DC and the second had a suboccipital decompression (SOC). Cerebral blood flow velocities (FV) and pulsatility indices (PI) were recorded via transcranial Doppler (TCD). To our knowledge, this is the first report on FV/PI monitoring after SOC. TCD is a readily available, non-invasive test. The PI may provide useful information regarding timing and effectiveness of DC.