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Glutathione spontaneously oxidizes in the UW solution for organ preservation and reduced glutathione (GSH) is converted to oxidized (GSSG) glutathione. To determine the effects of the oxidized or reduced forms of glutathione on liver preservation dog livers were preserved for 24 and 48 hr with the UW solution containing either GSH or GSSG. After 24 hr of preservation the form of glutathione did not affect survival or the postoperative course of the animals. All animals survived (three per group) with near-normal liver functions by the third to fifth postoperative day. When preservation was extended to 48 hr survival was 100% (6/6) with GSH and 29% (2/7) with GSSG. The dogs that died developed primary nonfunction of the liver. This study shows that GSH is an important component of the UW solution for 48-hr preservation of the dog liver. The presence of GSSG does not prevent successful 24-hr preservation of the liver, which has been confirmed in clinical studies. However, for 48-hr preservation GSH is required and GSSG is not suitable.
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
February 1978,
FEBS letters,
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
October 1998,
Journal of nutritional science and vitaminology,
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
April 1993,
Clinical chemistry,
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
January 2010,
Methods in molecular biology (Clifton, N.J.),
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
March 1981,
Neurochemical research,
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
March 1998,
European journal of clinical investigation,
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
April 2013,
Journal of cell science,
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
July 2008,
Journal of feline medicine and surgery,
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
June 1995,
Journal of gastroenterology,
K Boudjema, and
T M Van Gulik, and
S L Lindell, and
P S Vreugdenhil, and
J H Southard, and
F O Belzer
February 1987,
Neuroscience letters,
