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The data on the approbation of the diagnostic value of the enzyme immunoassay (EIA) system for the determination of diphtheria toxin in the blood sera of diphtheria patients and persons suspected for diphtheria are presented. The EIA system was prepared on the basis of F(ab)2 fractions of purified antidiphtheria antibodies. 240 serum samples from diphtheria and tonsillitis patients and from healthy persons were studied. Diphtheria toxin was determined in all patients with the toxic form of diphtheria and in 41.3% of patients with its localized forms. Blood was taken mainly of the first week of the disease. In healthy persons the results of EIA were negative. Thus, the trial of the assay system in a clinical laboratory showed its good diagnostic effectiveness. The use of this EIA system in medical practice is believed to be quite promising.
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
September 1987,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
November 1983,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
January 1992,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
January 1985,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
January 2000,
Voprosy virusologii,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
January 1988,
Laboratornoe delo,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
January 1985,
Laboratornoe delo,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
January 1988,
Trudy Instituta imeni Pastera,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
December 1990,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
N M Nikitiuk, and
L Iu Smurova, and
T S Shobukhova, and
T A Zykova, and
I N Filimonova, and
E B Ershova
January 1986,
Meditsinskaia parazitologiia i parazitarnye bolezni,
