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In a retrospective study of allograft rejections in renal transplant recipients we examined the value of cytokine production monitoring. Interleukin 1 (IL 1) and interleukin 2 (IL 2) activities were determined in supernatants of mitogen-stimulated peripheral blood lymphocytes in 8 renal transplant recipients serially for a period up to 60 days after transplantation. LPS-induced IL 1 as well as PHA-induced IL 2 production in patients after renal transplantation were significantly decreased in comparison to healthy controls. Seven episodes of cellular rejection were diagnosed in renal allograft recipients during this time, only 4 rejection episodes, however, were associated with a rise in the IL 1 and simultaneous IL 2 production occurred for 2 up to 3 days before the diagnosis of rejection. Moreover there were 12 instances in which an elevation of IL 1 and IL 2 production was found independently from the rejection. In 8 cases the augmentation of IL 1 and IL 2 production could be associated with clinical infections. We conclude from these results that a cytokine monitoring for the diagnosis of allograft rejection does not seem to be useful.
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
January 2015,
Annals of agricultural and environmental medicine : AAEM,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
August 1990,
Transplantation proceedings,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
January 1994,
Transplant international : official journal of the European Society for Organ Transplantation,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
May 2010,
Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
July 2004,
Calcified tissue international,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
January 1998,
Przeglad lekarski,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
August 1990,
Bone marrow transplantation,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
July 1994,
British journal of obstetrics and gynaecology,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
October 2000,
Ugeskrift for laeger,
S Buchwald, and
H Friemel, and
A Plantikow, and
B Hudemann, and
R Bast, and
R Templin
December 1970,
Langenbecks Archiv fur Chirurgie,
