On the mechanism of Candida spp. photoinactivation by hypericin. 2012

Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
IQS School of Engineering, Universitat Ramon Llull, Via Augusta, 390, 08017 Barcelona, Spain.

The photoprocesses involved in hypericin photoinactivation of three different Candida species (C. albicans, C. parapsilosis and C. krusei) have been examined. Production of singlet oxygen from the triplet state and of superoxide from both the triplet state and the semiquinone radical anion are demonstrated. Hydrogen peroxide is formed downstream of these early events. The outcome of the photodynamic treatments is dictated by the intracellular distribution of hypericin, which is different in the three species and affects the ability of hypericin to produce the different reactive oxygen species and trigger cell-death pathways. The results are in line with the previously-observed different susceptibilities of the three Candida species to hypericin photodynamic treatments.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008027 Light That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range. Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D008856 Microscopy, Fluorescence Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye. Fluorescence Microscopy,Immunofluorescence Microscopy,Microscopy, Immunofluorescence,Fluorescence Microscopies,Immunofluorescence Microscopies,Microscopies, Fluorescence,Microscopies, Immunofluorescence
D010569 Perylene A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic. Perilene,Peri-Dinaphthalene,Peri Dinaphthalene
D011838 Radiation-Sensitizing Agents Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells. Radiation Sensitizer,Radiosensitizing Agent,Radiosensitizing Agents,Agents, Radiation-Sensitizing,Radiation Sensitizers,Radiation Sensitizing Agents,Radiation-Sensitizing Drugs,Radiation-Sensitizing Effect,Radiation-Sensitizing Effects,Radiosensitizing Drugs,Radiosensitizing Effect,Radiosensitizing Effects,Agent, Radiosensitizing,Agents, Radiation Sensitizing,Agents, Radiosensitizing,Drugs, Radiation-Sensitizing,Drugs, Radiosensitizing,Effect, Radiation-Sensitizing,Effect, Radiosensitizing,Effects, Radiation-Sensitizing,Effects, Radiosensitizing,Radiation Sensitizing Drugs,Radiation Sensitizing Effect,Radiation Sensitizing Effects,Sensitizer, Radiation,Sensitizers, Radiation,Sensitizing Agents, Radiation
D002175 Candida A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; VULVOVAGINAL CANDIDIASIS; and CANDIDIASIS, ORAL (THRUSH). Candida guilliermondii var. nitratophila,Candida utilis,Cyberlindnera jadinii,Hansenula jadinii,Lindnera jadinii,Monilia,Pichia jadinii,Saccharomyces jadinii,Torula utilis,Torulopsis utilis,Monilias
D002176 Candida albicans A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis). Candida albicans var. stellatoidea,Candida stellatoidea,Dematium albicans,Monilia albicans,Myceloblastanon albicans,Mycotorula albicans,Parasaccharomyces albicans,Procandida albicans,Procandida stellatoidea,Saccharomyces albicans,Syringospora albicans
D006861 Hydrogen Peroxide A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D000873 Anthracenes A group of compounds with three aromatic rings joined in linear arrangement.
D016227 Benzoquinones Benzene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups. 1,2-Benzoquinones,1,4-Benzoquinones,Benzodiones,2,5-Cyclohexadiene-1,4-Diones,o-Benzoquinones,p-Benzoquinones

Related Publications

Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
June 2020, Photodiagnosis and photodynamic therapy,
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
February 2010, Current microbiology,
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
January 2012, Photochemistry and photobiology,
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
October 2014, Mycopathologia,
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
July 2023, Antibiotics (Basel, Switzerland),
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
April 1989, Journal of general microbiology,
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
January 1986, Doklady Akademii nauk SSSR,
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
October 1959, Mycopathologia et mycologia applicata,
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
March 2011, Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia,
Patricia López-Chicón, and Manuel P Paz-Cristobal, and Antonio Rezusta, and Carmen Aspiroz, and María Royo-Cañas, and Elena Andres-Ciriano, and Yolanda Gilaberte, and Montserrat Agut, and Santi Nonell
January 2019, Roczniki Panstwowego Zakladu Higieny,
Copied contents to your clipboard!