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Erythrocytes, suspended in a glucose-containing buffer, catalyzed the partial reduction of extracellular methemoglobin. Physiological concentrations of ascorbic acid or dehydroascorbic acid greatly enhanced the rate of reaction and the ultimate extent of reduction. The relationship between erythrocyte concentration and initial reaction rate was nonlinear, which suggested that the rate limiting factor was not an erythrocyte membrane enzyme. Also, significant dehydroascorbate-stimulated reduction occurred even when the erythrocytes and methemoglobin were separated by a dialysis membrane. The above observations indicate that the transfer of reducing equivalents across the erythrocyte membrane and reduction of extracellular methemoglobin can be accomplished by release and recycling of ascorbic acid.
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
January 1978,
Methods in enzymology,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
May 1977,
Experientia,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
December 1987,
Nihon Ika Daigaku zasshi,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
January 1947,
Federation proceedings,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
June 1959,
Acta physiologica Scandinavica,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
January 1981,
Progress in clinical and biological research,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
January 1949,
The Journal of biological chemistry,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
November 1979,
European journal of biochemistry,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
April 1978,
Experientia,
E L McGown, and
M F Lyons, and
M A Marini, and
A Zegna
January 1962,
Folia haematologica (Leipzig, Germany : 1928),
