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The ovaries of many species contain catecholamines and beta-adrenergic receptors. The present studies were done to determine if catecholamines play a role in the regulation of androgen production by porcine theca cells. Basal and luteinizing hormone (LH)-stimulated androstenedione production was significantly inhibited by noradrenaline and isoproterenol. The inhibitory effects were dose-dependent and were enhanced when the cultures contained the carboxy-O-methyl transferase inhibitor, U-0521. The inhibitory effect of isoproterenol was reversed by the beta-adrenergic antagonist, metoprolol. Isoproterenol caused a generalized inhibition of LH-stimulated steroidogenesis, decreasing the accumulation of pregnenolone, progesterone, androstenedione and estradiol in the culture medium. These studies suggest that catecholamines may be important regulators of thecal androgen production.
P Morley, and
F R Calaresu, and
D T Armstrong
April 1987,
Molecular and cellular endocrinology,
P Morley, and
F R Calaresu, and
D T Armstrong
June 1982,
Biology of reproduction,
P Morley, and
F R Calaresu, and
D T Armstrong
November 2004,
Molecular and cellular endocrinology,
P Morley, and
F R Calaresu, and
D T Armstrong
July 1989,
Endocrinology,
P Morley, and
F R Calaresu, and
D T Armstrong
May 1992,
Molecular and cellular endocrinology,
P Morley, and
F R Calaresu, and
D T Armstrong
April 1997,
Molecular human reproduction,
P Morley, and
F R Calaresu, and
D T Armstrong
August 1980,
Molecular and cellular endocrinology,
P Morley, and
F R Calaresu, and
D T Armstrong
January 1990,
Gynecologic and obstetric investigation,
P Morley, and
F R Calaresu, and
D T Armstrong
October 1991,
Endocrinology,
P Morley, and
F R Calaresu, and
D T Armstrong
February 1990,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
