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Lipid metabolism of intestine, liver and kidney was examined in daunomycin-induced nephrotic rats. 1) Phospholipids, triglycerides and cholesterol contents in chylomicrons were increased in daunomycin-induced nephrotic rats. 2) Cholesterol absorption in intestine (in vivo and situ) was similar in daunomycin-induced nephrotic rats and control rats. 3) Total bile acids levels in bile and portal vein were similar in two groups. 4) There was no difference in incorporation of 14C-mevalonate into cholesterol by liver and kidney slices in two groups. The oxidation of 14CO2 from 14C-mevalonate in kidney slices was decreased in daunomycin-induced nephrotic rats. These results show that the hypercholesterolemia in daunomycin-induced nephrotic rats are not caused by increased absorption of cholesterol in intestine. The increased cholesterol esters in liver are not derived from decreased bile acids catabolism. The increased cholesterogenesis in the liver of daunomycin-induced nephrotic rats may be due to an increased rate at the step prior to mevalonate. The oxidation of 14CO2 from mevalonate by shunt pathway may be decreased in the kidney of daunomycin-induced nephrotic rats.
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