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Performance on finger-tapping and handsteadiness, tasks opposite in response requirements, was compared between male smokers and nonsmokers (n = 10 each) on two occasions, once following intake of nicotine (15 micrograms/kg) by measured-dose nasal spray and once following placebo. Compared with nonsmokers, smokers had significantly greater increase in finger-tapping speed due to nicotine. On the other hand, smokers tended to have improved performance on handsteadiness (i.e., less involuntary movement) due to nicotine, while nonsmokers had impaired performance, although this difference was not significant. Nicotine-induced changes in performance on each task were inversely related, suggesting specificity of the behavioral effects of nicotine depending on task demands, rather than a generalized effect. These effects of nicotine on behavioral performance may be important in understanding the reinforcing value of nicotine intake, and differences in effects as a function of smoking history may suggest chronic adaptation to nicotine.
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
January 1994,
Clinical pharmacology and therapeutics,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
January 2005,
Physiology & behavior,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
March 1993,
Clinical pharmacology and therapeutics,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
January 1991,
Psychopharmacology,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
July 2006,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
January 1992,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
June 2003,
Archives of pediatrics & adolescent medicine,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
September 1996,
Psychopharmacology,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
September 2009,
Psychopharmacology,
K A Perkins, and
L H Epstein, and
R L Stiller, and
J E Sexton, and
T D Debski, and
R G Jacob
January 1990,
Psychopharmacology,
