[2 cases of severe hypokalemia with acute rhabdomyolysis]. 1990

S Dal Fabbro, and L Salvadego, and A Bridda
Divisione Medica I, ULSS 3, Belluno.

We report two cases of acute rhabdomyolysis due to severe hypokalemia. The first case appears to be caused by a chronic dietary potassium deficiency, responsible also for the elevation of blood pressure and the impairment of myocardial contractility. The administration of hydrochlorothiazide, albeit associated with captopril, could have decompensated the potassium balance, thus precipitating the acute rhabdomyolysis. More commonly the second case is due to acute potassium losses induced by a trivial enteritis in a hypertensive patient who was taking thiazide diuretics for a long period of time. We emphasize that chronic dietary potassium deficiency may represent a predisposing variable to acute rhabdomyolysis, which is generally precipitated by the superimposition of other potassium lowering factors.

UI MeSH Term Description Entries
D007008 Hypokalemia Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed) Hypopotassemia,Hypokalemias,Hypopotassemias
D008297 Male Males
D004032 Diet Regular course of eating and drinking adopted by a person or animal. Diets
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006852 Hydrochlorothiazide A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. Dichlothiazide,Dihydrochlorothiazide,Esidrex,Esidrix,HCTZ,HydroDIURIL,Hypothiazide,Oretic,Sectrazide
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D012206 Rhabdomyolysis Necrosis or disintegration of skeletal muscle often followed by myoglobinuria. Rhabdomyolyses

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