-transparent.png){kind=logo}
ACTH possesses powerful immuno-suppressive properties and also retards healing by inhibiting fibroblast proliferation and the deposition of collagen. In the present work this hormone was used to test both the 'barrier' and 'immune' hypotheses relating to the failure of CNS regeneration after injury, dosages being administered which had been found to stimulate maximal adrenal production of glucocorticoids in control animals. Although the scarring in the CNS and the systemic humoral and cellular immune responses were significantly depressed, no increase in CNS axon growth was noted, even when large doses of thyroxine were added. We conclude that both 'immune' and 'barrier' hypotheses should be rejected, and that the beneficial effects of thyroxine treatment reported by some workers are not substantiated.
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
August 2000,
Acta neuropathologica,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
May 1973,
Experientia,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
March 1973,
Experientia,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
January 2022,
Seminars in immunology,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
August 1985,
Brain research,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
January 1998,
Medical and pediatric oncology,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
August 1986,
Neurosurgery,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
May 1988,
The Veterinary clinics of North America. Small animal practice,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
January 1980,
Advances in biochemical psychopharmacology,
M Berry, and
J Knowles, and
P Willis, and
A C Riches, and
G P Morgans, and
D Steers
January 2018,
Developmental dynamics : an official publication of the American Association of Anatomists,
