-transparent.png){kind=logo}
We investigated the effects of transforming growth factor beta (TGF beta) on the induction by interleukin-1 beta (IL-1 beta) of IL-6 in human monocytes. We found that IL-1 beta induced IL-6 messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant. TGF beta did not induce IL-6. In contrast, TGF beta added to the culture inhibited, in a dose-dependent manner, the induction of IL-6 by IL-1 at the level of messenger RNA and bioactivity. These results show that IL-1 beta is able to stimulate IL-6 production by monocytes, TGF beta, by inhibiting this effect, may play an important role in regulating the IL-1-mediated components of the inflammatory response.
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
May 1991,
Journal of immunology (Baltimore, Md. : 1950),
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
February 1994,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
November 1994,
Biochemical and biophysical research communications,
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
January 2022,
PloS one,
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
April 1992,
Journal of immunology (Baltimore, Md. : 1950),
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
July 1998,
Cytokine,
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
October 1990,
Blood,
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
December 1994,
Experimental dermatology,
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
September 1993,
Journal of immunology (Baltimore, Md. : 1950),
T Musso, and
I Espinoza-Delgado, and
K Pulkki, and
G L Gusella, and
D L Longo, and
L Varesio
May 1990,
Cytokine,
