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bcr breakpoint and prognosis of chronic phase chronic myeloid leukemia. 1990

P Benn, and G D Birnie, and E MacKenzie, and K I Mills

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011505 Protein-Tyrosine Kinases Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors. Tyrosine Protein Kinase,Tyrosine-Specific Protein Kinase,Protein-Tyrosine Kinase,Tyrosine Kinase,Tyrosine Protein Kinases,Tyrosine-Specific Protein Kinases,Tyrosylprotein Kinase,Kinase, Protein-Tyrosine,Kinase, Tyrosine,Kinase, Tyrosine Protein,Kinase, Tyrosine-Specific Protein,Kinase, Tyrosylprotein,Kinases, Protein-Tyrosine,Kinases, Tyrosine Protein,Kinases, Tyrosine-Specific Protein,Protein Kinase, Tyrosine-Specific,Protein Kinases, Tyrosine,Protein Kinases, Tyrosine-Specific,Protein Tyrosine Kinase,Protein Tyrosine Kinases,Tyrosine Specific Protein Kinase,Tyrosine Specific Protein Kinases
D011518 Proto-Oncogene Proteins Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity. Cellular Proto-Oncogene Proteins,c-onc Proteins,Proto Oncogene Proteins, Cellular,Proto-Oncogene Products, Cellular,Cellular Proto Oncogene Proteins,Cellular Proto-Oncogene Products,Proto Oncogene Products, Cellular,Proto Oncogene Proteins,Proto-Oncogene Proteins, Cellular,c onc Proteins
D002892 Chromosomes, Human, Pair 22 A specific pair of GROUP G CHROMOSOMES of the human chromosome classification. Chromosome 22
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D015466 Leukemia, Myeloid, Chronic-Phase The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase. Granulocytic Leukemia, Chronic, Stable-Phase,Leukemia, Granulocytic, Chronic-Phase,Leukemia, Myelogenous, Chronic-Phase,Leukemia, Myeloid, Stable-Phase,Myelogenous Leukemia, Chronic, Chronic-Phase,Myeloid Leukemia, Chronic, Chronic-Phase,Myeloid Leukemia, Chronic, Stable-Phase,Granulocytic Leukemia, Chronic, Stable Phase,Leukemia, Granulocytic, Chronic Phase,Leukemia, Myelogenous, Chronic Phase,Leukemia, Myeloid, Chronic Phase,Leukemia, Myeloid, Stable Phase,Myelogenous Leukemia, Chronic, Chronic Phase,Myeloid Leukemia, Chronic, Chronic Phase
D051562 Proto-Oncogene Proteins c-bcr A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients. bcr Proto-Oncogene Proteins,c-bcr Proteins,Breakpoint Cluster Region Protein,Proto-Oncogene Protein bcr,Proto-Oncogene Protein c-bcr,c-bcr Proto-Oncogene Proteins,Proto Oncogene Protein bcr,Proto Oncogene Protein c bcr,Proto Oncogene Proteins c bcr,Proto-Oncogene Proteins, bcr,Proto-Oncogene Proteins, c-bcr,bcr Proto Oncogene Proteins,c bcr Proteins,c bcr Proto Oncogene Proteins,c-bcr, Proto-Oncogene Protein,c-bcr, Proto-Oncogene Proteins

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