Biomaterial Database

Dental stem cells for craniofacial tissue engineering. 2012

Elsa Machado, and Maria Helena Fernandes, and Pedro de Sousa Gomes

Laboratório de Farmacologia e Biocompatibilidade Celular, Faculdade de Medicina Dentária, Universidade do Porto, Porto, Portugal.

This article focuses on the biological characterization and discussion of the potential application of oral-derived adult stem cells for craniofacial tissue engineering applications. The authors reviewed experimental (in vitro and in vivo) and clinical reports regarding the isolation, characterization, modulation, and translational clinical application of human precursor cell populations derived from postnatal dental tissues. Five different human dental stem/progenitor cell populations have been isolated and characterized. These postnatal populations present mesenchymal stem cell-like characteristics and enjoy forceful capabilities regarding the differentiation into odontogenic/osteogenic lineages, supporting evidence--in preclinical and clinical trials--for the regeneration of oral/dental tissues.

UI	MeSH Term	Description	Entries
D009805	Odontogenesis	The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).	Odontogeneses
D010486	Periapical Tissue	Tissue surrounding the apex of a tooth, including the apical portion of the periodontal membrane and alveolar bone.	Periodontium, Apical,Apical Periodontium,Apical Periodontiums,Periapical Tissues,Periodontiums, Apical,Tissue, Periapical,Tissues, Periapical
D010513	Periodontal Ligament	The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).	Alveolodental Ligament,Alveolodental Membrane,Gomphosis,Alveolodental Ligaments,Alveolodental Membranes,Gomphoses,Ligament, Alveolodental,Ligament, Periodontal,Membrane, Alveolodental,Periodontal Ligaments
D001861	Bone Regeneration	Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.	Osteoconduction,Bone Regenerations,Regeneration, Bone,Regenerations, Bone
D003782	Dental Pulp	A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992)	Dental Pulps,Pulp, Dental,Pulps, Dental
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012886	Skull	The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.	Calvaria,Cranium,Calvarium,Skulls
D014083	Tooth Germ	The collective tissues from which an entire tooth is formed, including the DENTAL SAC; ENAMEL ORGAN; and DENTAL PAPILLA. (From Jablonski, Dictionary of Dentistry, 1992)	Germ, Tooth,Germs, Tooth,Tooth Germs
D014094	Tooth, Deciduous	The teeth of the first dentition, which are shed and replaced by the permanent teeth.	Primary Tooth,Tooth, Primary,Baby Teeth,Baby Tooth,Dentition, Deciduous,Dentition, Primary,Milk Teeth,Milk Tooth,Primary Teeth,Teeth, Deciduous,Teeth, Primary,Deciduous Dentition,Deciduous Dentitions,Deciduous Teeth,Deciduous Tooth,Dentitions, Deciduous,Dentitions, Primary,Primary Dentition,Primary Dentitions,Teeth, Baby,Teeth, Milk,Tooth, Baby,Tooth, Milk
D053687	Adult Stem Cells	Tissue-specific stem cells (also known as Somatic Stem Cells) that appear during fetal development and remain in the body throughout life. The key functions of adult stem cells are to maintain and repair the specific tissues where they reside (e.g. skin or blood).	Adult Somatic Stem Cells,Somatic Adult Stem Cells,Somatic Stem Cells,Adult Stem Cell,Somatic Stem Cell,Stem Cell, Somatic,Stem Cells, Adult,Stem Cells, Somatic