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Immuno-cross-reactivity between histidine decarboxylase (HDC) and dopa decarboxylase (DDC) was investigated. By comparing the cDNA sequences of rat HDC with rat and guinea-pig DDCs, we found a region that may possibly be related to the cross-reactivity of anti-rat HDC antibody with guinea-pig DDC. The peptide encoded by this region was synthesized and anti-peptide antibody was prepared. We also purified HDC and DDC homogeniously from fetal rat liver and guinea-pig liver, respectively. On immunoblotting, anti-peptide antibody recognized both rat HDC and guinea-pig DDC. Anti-HDC polyclonal antibody which also recognizes both enzymes detected only rat HDC when it was absorbed by the peptide. This result indicates that this region is responsible for the immuno-cross-reactivity of anti-rat HDC antibody with guinea-pig DDC.
H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
November 1986,
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H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
January 1967,
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H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
January 1963,
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H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
October 1961,
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H Mizuguchi, and
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H Wada
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Archives internationales de pharmacodynamie et de therapie,
H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
February 1971,
British journal of pharmacology,
H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
March 2007,
Dental materials : official publication of the Academy of Dental Materials,
H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
March 1998,
Veterinary parasitology,
H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
August 1969,
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H Mizuguchi, and
M Yabumoto, and
I Imamura, and
H Fukui, and
H Wada
September 2013,
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,
