Biomaterial Database

Absorption of sulfamethoxazole and albumin from the peritoneal cavity. 1990

J Rubin, and A Planch

Department of Medicine, University of Mississippi Medical Center, Jackson 39216-4105.

The rates of disappearance of sulfamethoxazole and albumin from the peritoneal cavity were measured in humans. Albumin was added to the peritoneal cavity in concentrations commonly found during peritonitis (250-500 mg/100 ml) to ascertain if protein binding within the peritoneal cavity inhibited absorption from the peritoneal cavity. There were no statistical differences between the removal rates; 64-70% of the administered dose was absorbed after 180 min of intraperitoneal residence. The addition of albumin to the peritoneal cavity did not alter absorption of sulfamethoxazole. The total protein removed in dialysate effluent in the absence of albumin was 1,653 +/- 906 mg. The protein losses when albumin was added to dialysate [( albumin + control losses] - losses in dialysate drainage) were 1,037 +/- 2,305 mg and 1,364 +/- 1,653 mg for the 6 and 12 g studies.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010529	Peritoneal Cavity	The space enclosed by the peritoneum. It is divided into two portions, the greater sac and the lesser sac or omental bursa, which lies behind the STOMACH. The two sacs are connected by the foramen of Winslow, or epiploic foramen.	Greater Sac,Lesser Sac,Omental Bursa,Bursa, Omental,Cavity, Peritoneal,Sac, Greater,Sac, Lesser
D010531	Peritoneal Dialysis, Continuous Ambulatory	Portable peritoneal dialysis using the continuous (24 hours a day, 7 days a week) presence of peritoneal dialysis solution in the peritoneal cavity except for periods of drainage and instillation of fresh solution.	CAPD,Continuous Ambulatory Peritoneal Dialysis
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000418	Albumins	Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.	Albumin
D015314	Dialysis Solutions	Solutions prepared for exchange across a semipermeable membrane of solutes below a molecular size determined by the cutoff threshold of the membrane material.	Dialysate,Dialysis Solution,Dialyzate,Dialysates,Dialyzates,Solution, Dialysis,Solutions, Dialysis
D015662	Trimethoprim, Sulfamethoxazole Drug Combination	A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.	Trimethoprim-Sulfamethoxazole Combination,Abactrim,Bactifor,Bactrim,Biseptol,Biseptol-480,Centran,Centrin,Co-Trimoxazole,Cotrimoxazole,Drylin,Eslectin,Eusaprim,Insozalin,Kepinol,Kepinol Forte,Lescot,Metomide,Oriprim,Septra,Septrin,Sulfamethoxazole-Trimethoprim Combination,Sulprim,Sumetrolim,TMP SMX,TMP-SMX,Trimedin,Trimethoprim-Sulfamethoxazole,Trimethoprimsulfa,Trimezole,Trimosulfa,Biseptol 480,Biseptol480,Co Trimoxazole,Sulfamethoxazole Trimethoprim Combination,Trimethoprim Sulfamethoxazole,Trimethoprim Sulfamethoxazole Combination