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Renal neurotransmission and its modulation by prostaglandin (PG) E2 (0.06 microM) and indomethacin (10 microM) was investigated in isolated kidneys of adult spontaneously hypertensive (SHR) and normotensive control (WKY) rats. After preincubation with [3H]-noradrenaline the renal nerves were stimulated. The stimulation induced (S-I) outflow of radioactivity was taken as an index of noradrenaline release. The S-I outflow of radioactivity from SHR and WKY kidneys was similar but S-I pressor responses were enhanced in kidneys of SHR. PGE2 inhibited and indomethacin enhanced the S-I outflow of radioactivity in kidneys of WKY and SHR to a similar extent. This inhibitory effect of PGE2 is due to activation of inhibitory prejunctional PGE2 receptors. Neuronally released noradrenaline stimulates a local formation of PGE2 which then transjunctionally inhibits noradrenaline release. Renal noradrenaline release in the adult SHR and its modulation by PGs is not altered. An enhanced postjunctional responsiveness of the renal vasculature may contribute to the maintenance of hypertension in the adult SHR.
L C Rump, and
K Wilde, and
P Schollmeyer
July 1977,
The American journal of physiology,
L C Rump, and
K Wilde, and
P Schollmeyer
February 1981,
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L C Rump, and
K Wilde, and
P Schollmeyer
June 1995,
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L C Rump, and
K Wilde, and
P Schollmeyer
January 1981,
Hypertension (Dallas, Tex. : 1979),
L C Rump, and
K Wilde, and
P Schollmeyer
April 1985,
Journal of hypertension,
L C Rump, and
K Wilde, and
P Schollmeyer
December 1979,
Clinical science (London, England : 1979),
L C Rump, and
K Wilde, and
P Schollmeyer
December 1976,
Research communications in chemical pathology and pharmacology,
L C Rump, and
K Wilde, and
P Schollmeyer
November 1991,
The Journal of physiology,
L C Rump, and
K Wilde, and
P Schollmeyer
January 1988,
Nihon Naibunpi Gakkai zasshi,
L C Rump, and
K Wilde, and
P Schollmeyer
January 1978,
The Chinese journal of physiology,
