BIOMAT Database Logo BIOMAT Database Logo

Comparison of oral erythromycin ethylsuccinate and ciprofloxacin in the treatment of acute respiratory tract infections. 1990

M S Feld, and C Carnegie, and J Macklin, and S Coles
Gresford Medical Centre, Maidenhead.

A total of 619 patients with acute upper or lower respiratory tract infection were randomised to receive either erythromycin ethylsuccinate tablets at a dose of 1 g twice daily, or ciprofloxacin tablets 500 mg twice daily in a single-blind, multicentre study. The efficacy of each antibacterial was similar, with close to 90% of patients on each treatment being reported as either cured or improved. Gastrointestinal symptoms were the most commonly reported side-effects, being similar in overall incidence for both agents. Nausea, vomiting, dizziness and headache occurred more frequently in the ciprofloxacin group, while abdominal pain and diarrhoea occurred more frequently in the erythromycin ethylsuccinate group. In each group, the number of patients failing to complete treatment was similar and the main reasons cited for discontinuation were gastrointestinal symptoms. This study indicates that both erythromycin ethylsuccinate and ciprofloxacin are well tolerated and are equally effective for routine empirical treatment of acute respiratory tract infections.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012141 Respiratory Tract Infections Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases. Respiratory System Infections,Upper Respiratory Tract Infection,Upper Respiratory Tract Infections,Infections, Respiratory,Infections, Respiratory Tract,Infections, Upper Respiratory,Infections, Upper Respiratory Tract,Respiratory Infections,Upper Respiratory Infections,Infection, Respiratory System,Infection, Respiratory Tract,Respiratory Infection, Upper,Respiratory System Infection,Respiratory Tract Infection
D002939 Ciprofloxacin A broad-spectrum antimicrobial carboxyfluoroquinoline. Bay-09867,Ciprinol,Cipro,Ciprofloxacin Hydrochloride,Ciprofloxacin Hydrochloride Anhydrous,Ciprofloxacin Monohydrochloride Monohydrate,Anhydrous, Ciprofloxacin Hydrochloride,Bay 09867,Bay09867,Hydrochloride Anhydrous, Ciprofloxacin,Hydrochloride, Ciprofloxacin,Monohydrate, Ciprofloxacin Monohydrochloride,Monohydrochloride Monohydrate, Ciprofloxacin
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D015643 Erythromycin Ethylsuccinate A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Monomycin,E-Mycin E,EryPed,Erythroped,Eyrthromycin Ethyl Succinate,Pediamycin,Wyamycin E,EMycin E,Ethyl Succinate, Eyrthromycin,Ethylsuccinate, Erythromycin,Succinate, Eyrthromycin Ethyl

Related Publications

M S Feld, and C Carnegie, and J Macklin, and S Coles
Comparison of oral erythromycin ethylsuccinate and clavulanate-potentiated amoxicillin in the treatment of acute respiratory tract infections.
January 1989, Clinical therapeutics,
M S Feld, and C Carnegie, and J Macklin, and S Coles
Flurithromycin ethylsuccinate in the treatment of lower respiratory tract bacterial infections.
January 1994, Infection,
M S Feld, and C Carnegie, and J Macklin, and S Coles
Comparison of two oral forms of erythromycin in the treatment of acute respiratory tract infections. A multicentre general practice study.
January 1989, The Journal of international medical research,
M S Feld, and C Carnegie, and J Macklin, and S Coles
[Ciprofloxacin in the treatment of respiratory tract infections].
January 1993, Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
M S Feld, and C Carnegie, and J Macklin, and S Coles
Treatment of respiratory tract infections with ciprofloxacin.
November 1986, The Journal of antimicrobial chemotherapy,
M S Feld, and C Carnegie, and J Macklin, and S Coles
Comparison of erythromycin estolate and erythromycin ethylsuccinate for treatment of pertussis. The Erythromycin Study Group.
March 1992, The Pediatric infectious disease journal,
M S Feld, and C Carnegie, and J Macklin, and S Coles
[Multicenter study of the clinical efficacy and tolerance of roxithromycin compared to erythromycin ethylsuccinate in lower respiratory tract infections].
May 1988, Pathologie-biologie,
M S Feld, and C Carnegie, and J Macklin, and S Coles
[Ciprofloxacin in the treatment of lower respiratory tract infections].
January 1993, Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
M S Feld, and C Carnegie, and J Macklin, and S Coles
A comparison of the erythromycin estolate and tetracycline in the treatment of respiratory tract infections.
August 1970, The Journal of the Royal College of General Practitioners,
M S Feld, and C Carnegie, and J Macklin, and S Coles
Comparison of erythromycin acistrate and enterocoated erythromycin base in acute respiratory infections.
June 1988, The Journal of antimicrobial chemotherapy,
Copied contents to your clipboard!