Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis. 2012

Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

The aim of this study was to determine whether maternal serum C-reactive protein (CRP) is of value in predicting funisitis and early-onset neonatal sepsis (EONS) in women with preterm labor or preterm premature rupture of membranes (PROM). This retrospective cohort study included 306 consecutive women with preterm labor or preterm PROM who delivered preterm singleton neonates (23-35 weeks gestation) within 72 hr of CRP measurement. The CRP level was measured with a highly sensitive immunoassay. The sensitivity, specificity, positive predictive value, and negative predictive value of an elevated serum CRP level (≥ 8 mg/L) were 74.1%, 67.5%, 32.8%, and 92.4% for funisitis, and 67.7%, 63.3%, 17.2%, and 94.6% for EONS, respectively. Logistic regression analysis demonstrated that elevated levels of serum CRP were significantly associated with funisitis and EONS, even after adjusting gestational age. The maternal serum CRP level obtained up to 72 hr before delivery is an independent predictor of funisitis and EONS in women with preterm labor or preterm PROM. A low serum CRP level (< 8 mg/L) has good negative predictive value in excluding funisitis and EONS, and may therefore be used as a non-invasive adjunct to clinical judgment to identify low-risk patients.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007234 Infant, Premature A human infant born before 37 weeks of GESTATION. Neonatal Prematurity,Premature Infants,Preterm Infants,Infant, Preterm,Infants, Premature,Infants, Preterm,Premature Infant,Prematurity, Neonatal,Preterm Infant
D007235 Infant, Premature, Diseases Diseases that occur in PREMATURE INFANTS.
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002097 C-Reactive Protein A plasma protein that circulates in increased amounts during inflammation and after tissue damage. C-Reactive Protein measured by more sensitive methods often for coronary heart disease risk assessment is referred to as High Sensitivity C-Reactive Protein (hs-CRP). High Sensitivity C-Reactive Protein,hs-CRP,hsCRP,C Reactive Protein,High Sensitivity C Reactive Protein
D002821 Chorioamnionitis INFLAMMATION of the placental membranes (CHORION; AMNION) and connected tissues such as fetal BLOOD VESSELS and UMBILICAL CORD. It is often associated with intrauterine ascending infections during PREGNANCY. Amnionitis,Funisitis,Amnionitides,Chorioamnionitides,Funisitides
D005260 Female Females
D005322 Fetal Membranes, Premature Rupture Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION. Premature Rupture of Membrane (Pregnancy),PROM (Pregnancy),Premature Rupture of Fetal Membranes,Preterm PROM (Pregnancy),Preterm Premature Rupture of Fetal Membranes,Membrane Premature Rupture (Pregnancy),Membrane Premature Ruptures (Pregnancy),PROM, Preterm (Pregnancy)
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages

Related Publications

Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
June 2021, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
January 2021, JAMA pediatrics,
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
January 2021, JAMA pediatrics,
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
January 2002, Acta medica (Hradec Kralove),
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
December 1985, Journal of the Indian Medical Association,
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
April 2021, Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia,
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
September 2016, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
March 2020, JAMA pediatrics,
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
January 2008, Srpski arhiv za celokupno lekarstvo,
Sung Youn Lee, and Kyo Hoon Park, and Eun Ha Jeong, and Kyung Joon Oh, and Aeli Ryu, and Kyoung Un Park
January 2022, Psychology, health & medicine,
Copied contents to your clipboard!