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The brain and skeletal muscle of eight adult patients with migraine with prolonged auras or migraine strokes leaving a permanent hemianopic defect were studied by phosphorus magnetic resonance spectroscopy. Biochemical assays performed on muscle biopsy and platelets had revealed abnormal mitochondrial enzyme activities. Brain magnetic resonance spectroscopy showed an abnormally low phosphocreatine to inorganic phosphate ratio in all patients, apparently due to decreased phosphocreatine and increased inorganic phosphate contents. Muscle phosphorus magnetic resonance spectroscopy showed low recovery from exercise in seven patients. Three patients had an increased phosphocreatine/inorganic phosphate ratio at rest, and the exercise transfer characteristics were abnormal in four patients for relatively low levels of exercise. The mitochondrial metabolic defects present in platelets and muscle of complicated migraine patients are therefore also expressed in the brain.
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
July 1991,
Cephalalgia : an international journal of headache,
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
January 1992,
The Journal of clinical endocrinology and metabolism,
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
December 1991,
Journal of hand surgery (Edinburgh, Scotland),
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
September 1988,
Archives internationales de physiologie et de biochimie,
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
April 1991,
Biochemical Society transactions,
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
January 1995,
Cephalalgia : an international journal of headache,
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
June 1994,
British journal of cancer,
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
January 1989,
Cerebrovascular and brain metabolism reviews,
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
January 1999,
Epilepsia,
B Barbiroli, and
P Montagna, and
P Cortelli, and
P Martinelli, and
T Sacquegna, and
P Zaniol, and
E Lugaresi
November 1991,
Muscle & nerve,
