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No information is available on the pharmacological effect of bradykinin to lymphocytes and immunological responses of them. In this study it was clarified that bradykinin as well as histamine elevated cyclic adenosine 3',5' monophosphate (cAMP) levels of murine splenic or lymph node lymphocytes and mature thymocytes (cortisone-resistant thymus), but did not increase cAMP levels of immature thymocytes as well as histamine. The increased cAMP ratios in T cell-enriched splenic lymphocytes by the impulse of bradykinin were higher than that in splenic and lymph node lymphoid cells by the stimulation of bradykinin. It was also demonstrated that bradykinin as well as histamine suppressed DNA synthesis by mitogenic (PHA-P, Con-A) stimulation of splenic lymphocytes, but not a effect to the response of lymphocytes by mitogenic (LPS) stimulation was observed. These facts suggest that bradykinin may play an important role in the regulation of immunologic lymphocyte responses.
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
December 1978,
Cellular immunology,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
August 1992,
Immunology letters,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
April 1980,
Biochimica et biophysica acta,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
February 1977,
Diabetes,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
March 1971,
The Journal of physiology,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
October 2004,
Nucleosides, nucleotides & nucleic acids,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
January 1982,
International journal of immunopharmacology,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
May 1981,
Cellular immunology,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
May 1984,
Bollettino della Societa italiana di biologia sperimentale,
Y Kimura, and
T Fujihira, and
K Kato, and
M Furuya, and
M Onda, and
A Shirota
September 1974,
Nature,
