BIOMAT Database Logo BIOMAT Database Logo

[The diminishing oocyte toxicity following intraperitoneal infusion of cisplatin (CDDP) combined with subcutaneous injection of sodium thiosulfate (STS) in syngeneic young mice]. 1990

K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
Department of Obstetrics and Gynecology, Tokyo Women's Medical College.

Small oocytes in 6-week-old C57BL/6 mice were destroyed in a dose-dependent fashion following intraperitoneal infusion of CDDP. ED65, the effective dose of which theoretically produced 65% destruction of small oocytes according to Probit analysis, was determined as 0.2mg/mouse. In this study, the oocyte toxicity induced with intraperitoneal treatment with CDDP (0.2mg) was offset by subcutaneous treatment with STS (40mg, 400 x molar ratio compared to that of CDDP). STS was subcutaneously injected into the back skin of mice at 60, 30, 15 minutes before, at the same time or at 15, 30, 60 minutes after the CDDP injection. STS markedly diminished the oocyte toxicity and reduced oocyte destruction about 45% when it was injected at 30, 15 minutes before or at the same time as CDDP infusion. On the other hand STS failed to reduce oocyte destruction when it was injected 15, 30 or 60 minutes later. STS might neutralize CDDP in the circulating blood to decrease the amount of active CDDP, but STS might not have any effect on CDDP once it is incorporated and conjugated with the DNA in the oocytes.

UI MeSH Term Description Entries
D007274 Injections, Intraperitoneal Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall. Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D007279 Injections, Subcutaneous Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin. Subcutaneous Injections,Injection, Subcutaneous,Subcutaneous Injection
D009865 Oocytes Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM). Ovocytes,Oocyte,Ovocyte
D002452 Cell Count The number of CELLS of a specific kind, usually measured per unit volume or area of sample. Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013885 Thiosulfates Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3. Thiosulfate

Related Publications

K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
[Systemic chemotherapy with super-high dose cisplatin and sodium thiosulfate (STS) rescue in mice].
April 1985, Gan to kagaku ryoho. Cancer & chemotherapy,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
Sodium thiosulfate protects from renal impairement following hyperthermic intraperitoneal chemotherapy (HIPEC) with Cisplatin.
January 2020, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
Intraperitoneal cisplatin with sodium thiosulfate protection in rats with intestinal anastomoses.
April 1993, Journal of surgical oncology,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
Sodium thiosulfate for postoperative cisplatin induced nephrotoxicity following hyperthermic intraperitoneal chemotherapy: A case report.
May 2021, Gynecologic oncology reports,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
[Experimental chemotherapy with super-high dose cisplatin and sodium thiosulfate (STS) rescue: its effect on survival and nephrotoxicity in mice].
June 1985, Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
Effect of sodium thiosulfate on the pharmacokinetics and toxicity of cisplatin.
October 1989, Journal of the National Cancer Institute,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
[Pharmacokinetics following intraperitoneal infusion of cisplatinum with and without sodium thiosulfate rescue in carcinomatous peritonitis in advanced gastric cancers].
August 1991, Gan to kagaku ryoho. Cancer & chemotherapy,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
[Systemic chemotherapy with cisplatin and sodium thiosulfate (STS) rescue--its effect on the antitumor activity of cisplatin and the total platinum concentration in tumor bearing nude mice].
April 1986, Nihon Gan Chiryo Gakkai shi,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
[Pharmacokinetic study of cisplatin and sodium thiosulfate in two-route-infusion chemotherapy].
April 1986, Gan to kagaku ryoho. Cancer & chemotherapy,
K Takizawa, and I Yokoo, and Y Shima, and I Ozaki, and M Sato, and T Iguchi, and Y Takeda
Evaluation of ototoxicity in patients treated with hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin and sodium thiosulfate.
January 2014, Ear and hearing,
Copied contents to your clipboard!