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Effect of food on the bioavailability of bromazepam following oral administration in healthy volunteers. 1990

J Fujii, and N Inotsume, and M Nakano
Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.

The effect of food on the rate and extent of bioavailability of bromazepam was examined in seven normal volunteers following a single oral dose of 10 mg bromazepam with 200 ml of water in the fasting and non-fasting states. Plasma concentrations of bromazepam were measured by high pressure liquid chromatography. A tmax value in a non-fasting state was prolonged from 2.3 +/- 0.3 (mean +/- S.E.M.) to 2.8 +/- 0.6 h but not significantly different (p greater than 0.05) whereas a Cmax value was significantly (p less than 0.05) decreased from 259 +/- 12.7 (mean +/- S.E.M.) to 169 +/- 13.9 ng/ml. The area under the plasma concentration-time curve in the non-fasting state was also significantly (p less than 0.05) decreased from 1844 +/- 145 (mean +/- S.E.M.) to 1233 +/- 98.1 ng.h/ml after oral administration of bromazepam.

UI MeSH Term Description Entries
D008297 Male Males
D001960 Bromazepam One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS. Anxyrex,Apo-Bromazepam,BromaLich,Bromaz 1A Pharma,Bromazanil,Bromazep Von Ct,Bromazepam AL,Bromazepam Beta,Bromazepam Heumann,Bromazepam-Neuraxpharm,Bromazepam-Ratiopharm,Durazanil,Gen-Bromazepam,Lexatin,Lexomil,Lexotan,Lexotanil,Ro 5-3350,Apo Bromazepam,Beta, Bromazepam,Bromazepam Neuraxpharm,Bromazepam Ratiopharm,Gen Bromazepam,Ro 53350,Von Ct, Bromazep
D005260 Female Females
D005502 Food Substances taken in by the body to provide nourishment. Foods
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000042 Absorption The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001682 Biological Availability The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action. Availability Equivalency,Bioavailability,Physiologic Availability,Availability, Biologic,Availability, Biological,Availability, Physiologic,Biologic Availability,Availabilities, Biologic,Availabilities, Biological,Availabilities, Physiologic,Availability Equivalencies,Bioavailabilities,Biologic Availabilities,Biological Availabilities,Equivalencies, Availability,Equivalency, Availability,Physiologic Availabilities

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