-transparent.png){kind=logo}
Epidermal growth factor receptor (EGF-R) of fibroblasts from 3 patients with scleroderma (progressive systemic sclerosis, PSS) was studied by radioiodinated-EGF binding assay. The binding was 60.9 +/- 4.0% of normal fibroblasts, and the Scatchard plots showed a decrease in the affinity for EGF, not in the number of EGF-R. PSS fibroblasts expressed higher levels (1.15-2.45-fold) of RNA for the v-erbB (EGF-R gene). All-transretinoic acid (retinoid) had little effect on EGF-R, v-erbB gene expression and the proliferation of PSS fibroblasts. These data concerning the abnormality in the EGF-R may all constitute a feature of PSS fibroblasts.
Related Publications
K Tokiyama, and
E Yokota, and
Y Niho
December 1998,
Microscopy research and technique,
K Tokiyama, and
E Yokota, and
Y Niho
June 2003,
Arthritis and rheumatism,
K Tokiyama, and
E Yokota, and
Y Niho
January 1984,
Cell,
K Tokiyama, and
E Yokota, and
Y Niho
December 2022,
Cancer,
K Tokiyama, and
E Yokota, and
Y Niho
January 2000,
Free radical biology & medicine,
K Tokiyama, and
E Yokota, and
Y Niho
May 1996,
Biochemistry,
K Tokiyama, and
E Yokota, and
Y Niho
January 1975,
Advances in metabolic disorders,
K Tokiyama, and
E Yokota, and
Y Niho
May 1994,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
K Tokiyama, and
E Yokota, and
Y Niho
September 2013,
Cancer science,
K Tokiyama, and
E Yokota, and
Y Niho
January 1992,
Revista medica de Chile,
