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Effects of several kinds of ginsenosides, saponins from Panax ginseng on DNA, RNA, protein and lipid synthesis in bone marrow were investigated. Single i.p. injection of 0.5--1 mg/100 g body weight of ginsenosides Rb2, Rc, Re and Rg1 4 h prior to the sacrifice increased DNA synthesis in bone marrow cells. RNA, protein and lipid synthesis were also increased. The direct addition of ginsenosides Rb1, Rb2 and Rc mixture (GNS) enhanced DNA synthesis. Cyclic AMP levels in bone marrow cells were decreased 20 min after i.p. injection of ginsenosides Rb2, Rc and Rg1 and the direct addition of ginsenosides Rb2, Rc and Rg1 also decreased cyclic AMP levels. While cyclic GMP levels were increased by administration of ginsenosides Rb2, Re and Rg1. Relationship between chemical structure and actions of ginsenosides and the role of cyclic nucleotides in the stimulatory action of ginsenosides on DNA synthesis in bone marrow cells were discussed.
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
January 1977,
Arzneimittel-Forschung,
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
December 1973,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
July 1977,
Arzneimittel-Forschung,
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
January 1975,
Immunological communications,
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
June 1980,
Biokhimiia (Moscow, Russia),
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
October 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
April 1972,
FEBS letters,
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
July 1975,
Archives internationales de pharmacodynamie et de therapie,
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
January 1978,
Radiobiologiia,
M Yamamoto, and
M Masaka, and
K Yamada, and
Y Hayashi, and
A Hirai, and
A Kumagai
March 1954,
Science (New York, N.Y.),
