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To clarify side effects in children, which resulted from the treatment of intrathoracic tuberculosis with rifampicin, 72 patients were examined. The findings were compared with those on 58 identical patients who received a routine combination of chemotherapeutic drugs. Hence, on the basis of this observation it was found that there were no differences in the incidence of adverse reactions in the compared groups, though their nature was varying. The children on rifampicin were observed to develop mild liver dysfunction 2.5 times more frequently. Besides, toxic-allergic reactions were recorded in the majority of the patients. The combination of isoniazid and rifampicin was proved to enhance their toxic and allergic effects. Liver dysfunction in the presence of different adverse reactions presented with a higher activity in the blood serum of indicator liver enzymes and its impaired protein-forming function.
K S Kazakov, and
R I Zakharova, and
F T Absadykova
June 1981,
Revista medica de Chile,
K S Kazakov, and
R I Zakharova, and
F T Absadykova
January 1988,
Problemy tuberkuleza,
K S Kazakov, and
R I Zakharova, and
F T Absadykova
October 1985,
Journal of the Indian Medical Association,
K S Kazakov, and
R I Zakharova, and
F T Absadykova
April 1987,
British medical journal (Clinical research ed.),
K S Kazakov, and
R I Zakharova, and
F T Absadykova
January 1994,
Klinicheskaia laboratornaia diagnostika,
K S Kazakov, and
R I Zakharova, and
F T Absadykova
January 1985,
Indian journal of dermatology, venereology and leprology,
K S Kazakov, and
R I Zakharova, and
F T Absadykova
January 2019,
Indian journal of dermatology,
K S Kazakov, and
R I Zakharova, and
F T Absadykova
February 2006,
Der Pathologe,
K S Kazakov, and
R I Zakharova, and
F T Absadykova
August 1978,
Problemy tuberkuleza,
K S Kazakov, and
R I Zakharova, and
F T Absadykova
July 1977,
Voprosy okhrany materinstva i detstva,
