Biomaterial Database

The influence of intravesical volume upon contractile responses of the whole bladder preparation from streptozotocin-diabetic rats. 1990

P A Longhurst, and J Kang, and A J Wein, and R M Levin

Division of Urology, Hospital of the University of Pennsylvania, Philadelphia 19104.

1. The in vivo whole bladder preparation was used to correlate bladder volume with the ability of urinary bladders from control, sucrose-drinking, and diabetic rats to develop pressure in response to bethanechol or nerve stimulation. 2. Both streptozotocin-induced diabetes mellitus and sucrose-diuresis caused an increase in rat urinary bladder capacity and mass. 3. There were significant decreases in the ability of bladders from control rats to develop pressure in response to bethanechol at 1.0 ml intravesical volume, but no change in responsiveness of bladders from sucrose-drinking or diabetic rats at different intravesical volumes. Bladders from sucrose-drinking and diabetic rats developed significantly less pressure in response to bethanechol stimulation at low intravesical volumes than did bladders from control rats. 4. Bladders from diabetic rats developed significantly less pressure in response to 32 Hz stimulation at 0.2 ml intravesical volume compared to larger volumes, however, there were no differences in the responses of bladders from sucrose-drinking or control rats at any intravesical volume. 5. Bladders from control and sucrose-drinking rats had a reduced ability to empty in response to bethanechol and field stimulation at large intravesical volumes. 6. Bladders from 8-week streptozotocin-diabetic rats are able to contract and empty efficiently in response to nerve stimulation and bethanechol over a wide range of intravesical volumes.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001743	Urinary Bladder	A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.	Bladder,Bladder Detrusor Muscle,Detrusor Urinae,Bladder Detrusor Muscles,Bladder, Urinary,Detrusor Muscle, Bladder,Detrusor Muscles, Bladder
D001786	Blood Glucose	Glucose in blood.	Blood Sugar,Glucose, Blood,Sugar, Blood
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D003921	Diabetes Mellitus, Experimental	Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.	Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses