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The effects of third ventricular injection of tetradecapeptide renin substrate (TDP) and natural renin substrate prepared from dog cerebrospinal fluid were compared in anesthetized dogs. Central injection of 350 pmol TDP caused a long lasting increase in arterial blood pressure, a reduction in PRA, and increases in plasma levels of vasopressin, and ACTH. In marked contrast, central administration of equimolar doses of natural renin substrate had no effect on these variables. Intracranial administration of the converting enzyme inhibitor SQ 20881 prevented the effects of central injection of TDP. Thus, TDP exerts its effects via conversion to angiotensin II and does not necessitate the postulation of the action of an enzyme with renin-like activity in the brain.
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
November 1974,
Acta pharmacologica et toxicologica,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
August 1985,
Artificial organs,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
April 1981,
Journal of clinical pharmacology,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
September 1958,
The Journal of experimental medicine,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
December 1978,
Clinical science and molecular medicine. Supplement,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
December 1983,
The Journal of pediatrics,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
October 1976,
The Medical journal of Australia,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
August 1982,
American heart journal,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
January 1980,
Archives of gynecology,
D J Ramsay, and
C Brown, and
I A Reid, and
L C Keil
June 1987,
Human nutrition. Applied nutrition,
