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BACKGROUND Obesity is a growing problem throughout Europe, where the rate has more than doubled over the past 20 years. Reduced circulating serotonin may contribute to the development of obesity. This study aimed to explore associations between whole blood (WB) serotonin concentrations and anthropometric measures. METHODS Healthy adult volunteers (N = 68) gave whole blood samples for measurement of WB serotonin, and underwent BMI waist circumference (WC) and waist-to-hip ratio (WHR) assessment as well as DEXA (dual energy X-ray absorptiometry) scans for anthropometric parameters. Student's t-tests determined differences in WB serotonin and anthropometric measures between sexes. Partial Pearson's correlations were carried out on anthropometric measures and WB serotonin. RESULTS For the whole sample, WB serotonin was significantly negatively correlated with BMI, WC, WHR as well as android, gynoid and total % body fat. Analysis by sex showed significant negative correlations between WB serotonin and android, gynoid as well as total fat in males, but not in females. CONCLUSIONS This dichotomy between the sexes implies that there may be sex differences in the way that serotonin interplays with the development of obesity and body fat distribution.
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
February 2006,
Biological psychology,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
February 2020,
Radiology. Cardiothoracic imaging,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
January 1988,
Journal of neural transmission,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
September 1995,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
November 2000,
Anesthesiology,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
January 1994,
European journal of clinical pharmacology,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
January 2005,
American journal of human genetics,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
October 2020,
Clinical pharmacology in drug development,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
January 2003,
The Clinical journal of pain,
Stephanie Hodge, and
Brendan P Bunting, and
Edwin Carr, and
J J Strain, and
Barbara J Stewart-Knox
November 1996,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
